Enhanced consumption of salient solutions following pedunculopontine tegmental lesions
نویسندگان
چکیده
منابع مشابه
Effects of pedunculopontine tegmental nucleus lesions on responding for intravenous heroin under different schedules of reinforcement.
The pedunculopontine tegmental nucleus (PPTg) is believed to play important roles in reward and learning. We examined the effect of PPTg lesions (0.5 microl of 0.1 M NMDA injected bilaterally over 10 min) on the learning of an operant response for opiate reward. In 14 adult male Long-Evans rats, bilateral lesions of the PPTg disrupted the acquisition of responding for intravenous heroin (0.1 mg...
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In this article, we address the role of neuronal activity in the pathways of the brainstem-midbrain circuit in reward and the basis for believing that this circuit provides advantages over previous reinforcement learning theory. Several lines of evidence support the reward-based learning theory proposing that midbrain dopamine (DA) neurons send a teaching signal (the reward prediction error sig...
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The dopamine system has been implicated in guiding behavior based on rewards. The pedunculopontine tegmental nucleus (PPTN) of the brainstem receives afferent inputs from reward-related structures, including the cerebral cortices and the basal ganglia, and in turn provides strong excitatory projections to dopamine neurons. This anatomical evidence predicts that PPTN neurons may carry reward inf...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2015
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2014.09.075